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Huffing solvents and propellants carries substantially greater risk both for death and for long-term neurocognitive damage than does the use of nitrite poppers. Popper use has a relaxation effect on involuntary smooth muscles, such as those in the throat and anus. Academic research on nitrites began around the s but came to mixed conclusions over its correlation with AIDs, HIV and Karposi's sarcoma. The first hit is no joke, but once my eyes stop watering and I bow my head for round two, I find I'm unable to repeat the euphoria I experienced just moments before. Retrieved 29 April

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Epidemiology and clinical management of inhaled nitrite abuse".

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